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Picroside II
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Picroside II图片
CAS NO:39012-20-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
20mg电议

产品介绍
Picroside II 是一种从 Picrorhiza 中提取的环烯醚萜类化合物,具有抗炎和抗凋亡活性。
Cas No.39012-20-9
别名胡黄连苷II
化学名[1a-(hydroxymethyl)-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-6-yl] 4-hydroxy-3-methoxybenzoate
Canonical SMILESCOC1=C(C=CC(=C1)C(=O)OC2C3C=COC(C3C4(C2O4)CO)OC5C(C(C(C(O5)CO)O)O)O)O
分子式C23H28O13
分子量512.46
溶解度≥ 22.9mg/mL in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

EC50: 50 g/mL

PicrosideII is a major an iridoid glucoside isolated from Picrorhiza scrophulariiflora Pennell (Scrophulariaceae). Previous studies have shown that picroside II can protect cardiomyocytes against oxidative stress induced by hypoxia/ reoxygenation (H/R) injury.

In vitro: Pretreated cardiomyocytes with picroside II was found to inhibit LDH activity in culture media and increase cell viability in a dose-dependent manner. Such protective effect was accompanied with significant reduction of GSH contents and the activities of SOD and GSH-Px. Attenuated MDA and GSSG contents in response to H/R injury were observed as well. In addition, picroside II treatment also inhibited calcium accumulation and ROS production in cardiomyocytes. [1].

In vivo: A rat focal cerebral ischemic model was established, and picroside II were given intraperitoneally. Results indicated that the damage to the structures of the neurons and the blood brain barrier (BBB) in the cortex was more severe in the model group. In the picroside II treatment group, the neurological function, the morphology and ultrastructure of the neurons, and the BBB were improved. In addition, apoptotic cell number, cerebral infarct volume, EAR and pERK1/2 expression were decreased significantly compared to the model group [2].

Clinical trial: N/A

References:
[1] Meng FJ,Hou ZW,Li Y,Yang Y,Yu B.  The protective effect of picroside II against hypoxia/reoxygenation injury in neonatal rat cardiomyocytes. Pharm Biol.2012 Oct;50(10):1226-32.
[2] Wang T,Zhao L,Guo Y,Zhang M,Pei H.  Picroside II Inhibits Neuronal Apoptosis and Improves the Morphology and Structure of Brain Tissue following Cerebral Ischemic Injury in Rats. PLoS One.2015 Apr 30;10(4):e0124099.