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Naringenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Naringenin图片
CAS NO:480-41-1
规格:≥98%
包装与价格:
包装价格(元)
1g电议
2g电议
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)272.25
FormulaC15H12O5
CAS No.480-41-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 54 mg/mL (198.3 mM)
Water: <1 mg/mL
Ethanol: 5 mg/mL (18.4 mM)
Solubility (In vivo)

Chemical Name: (S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one

InChi Key: FTVWIRXFELQLPI-ZDUSSCGKSA-N

InChi Code: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1

SMILES Code: O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13

SynonymsNSC 34875, S-Dihydrogenistein, NSC 11855; Salipurol; Naringenin;NSC-11855; NSC11855
实验参考方法
In Vitro

In vitro activity: Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances.


Cell Assay: Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay

In VivoIntragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice>5g/kg; Rats>5g/kg.
Animal modelRats
Formulation & Dosage50 mg/kg; i.g.
References

Carcinogenesis. 1990 Dec;11(12):2275-9; Diabetes Obes Metab. 2008 Nov;10(11):1097-104.