| CAS NO: | 1229652-21-4 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 1229652-21-4 |
| 化学名 | (Z)-(4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid |
| Canonical SMILES | FC1=CC=C(C=C1)CN2C(/C(SC2=O)=C/C(C=C3)=CC=C3OCC4=CC=C(B(O)O)C=C4)=O |
| 分子式 | C24H19BFNO5S |
| 分子量 | 463.29 |
| 溶解度 | DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 0.5 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1]. HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2]. References: |
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