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Edelfosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Edelfosine图片
CAS NO:77286-66-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Edelfosine ((R)-ET-18-OCH3) 是一种醚脂质类似物，具有抗 HIV 和抗肿瘤活性。
Cas No.77286-66-9
别名1-O-十八烷基-2-O-甲基-SN-甘油-3-磷酸,2-O-methyl PAF C-18
化学名(S)-2-methoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
Canonical SMILES[O-][P@@](OCC[N+](C)(C)C)(OC[C@H](COCCCCCCCCCCCCCCCCCC)OC)=O
分子式C27H58NO6P
分子量523.73
溶解度PBS pH 7.2: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.[1] In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.[2]

Reference:
[1]. van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22, 820-823 (1987).
[2]. Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Research 715, 98-103 (1996).