Rolitetracycline 是四环素的衍生物，是一种广谱抗生素。
| Cas No. | 751-97-3 |
| 别名 | 罗利环素/氢吡四环素 |
| 化学名 | 4-(dimethylamino)-1,4S,4aS,5,5aS,6S,11,12aS-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide |
| Canonical SMILES | OC([C@@](C(C(C(NCN1CCCC1)=O)=C(O)[C@H]2N(C)C)=O)(O)[C@@]2([H])C3)=C([C@@]3([H])[C@@]4(O)C)C(C5=C4C=CC=C5O)=O |
| 分子式 | C27H33N3O8 |
| 分子量 | 527.6 |
| 溶解度 | Water: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rolitetracycline is a tetracycline antibiotic with bacteriostatic activity at low concentrations (7.8 μg/ml) and bactericidal activity at high concentrations (15.6 μg/ml) against E. coli. It has additive and synergistic effects with penicillin and cephalothin, respectively, in vitro against 34 E. coli and S. aureus strains. Rolitetracycline is also active against P. falciparum strains (IC50s = 45-208 μM) that are susceptible and resistant to chloroquine . It also reduces amyloid-β (1-40) (Aβ40) fibrilization (IC50 = 59 μM in an immune assay) and completely inhibits Aβ40-induced cellular toxicity at a concentration of 20 μM. |
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