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DprE1-IN2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DprE1-IN2图片
CAS NO:1615713-87-5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
DprE1-IN2 (compound 18) 是一种有效的 DprE1 抑制剂,IC50 为 28 nM。
Cas No.1615713-87-5
化学名1-[[6-(dimethylamino)-5-methyl-4-pyrimidinyl]methyl]-N-(2-hydroxyethyl)-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
Canonical SMILESCC1=CN=C2C(N(CC3=C(C)C(N(C)C)=NC=N3)C=C2C(NCCO)=O)=C1
分子式C19H24N6O2
分子量368.4
溶解度DMF: 2mg/mL,DMSO: 2mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect[1].

DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice[1].

References:
[1]. Shirude PS et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37.