BM212 是一种有效的分枝杆菌膜蛋白 Large 3 (MmpL3) 抑制剂。
| Cas No. | 146204-42-4 |
| 化学名 | 1-[[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl]-4-methyl-piperazine |
| Canonical SMILES | CC1=C(CN2CCN(C)CC2)C=C(C3=CC=C(Cl)C=C3)N1C4=CC=C(Cl)C=C4 |
| 分子式 | C23H25Cl2N3 |
| 分子量 | 414.4 |
| 溶解度 | DMF: 0.5 mg/ml,Ethanol: 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BM212 is an antimycobacterial compound. It inhibits the growth of laboratory and clinical isolate M. tuberculosis strains (MICs = 0.7-1.5 μg/ml), including strains resistant to ethambutol , isoniazid , rifampicin , and rifabutin. BM212 also inhibits the growth of M. fortuitum, M. smegmatis, M. kansasii, and M. avium strains (MICs = 3.1-12.5, 3.1-25, 3.1-6.2, and 0.4-3.1 μg/ml, respectively). It inhibits replication of intracellular M. tuberculosis in infected U937 macrophages in a dose-dependent manner at concentrations ranging from 0.5-10 μg/ml. Some M. smegmatis, M. bovis BCG, and M. tuberculosis H37Rv mutant strains carry mutations in the mycobacterium membrane protein large 3 (mmpL3) gene and are resistant to BM212, indicating mmpL3 is likely a cellular target of BM212. |
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