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AN3365(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AN3365(hydrochloride)图片
CAS NO:1234563-16-6
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Epetraborole (GSK2251052) hydrochloride 是一种新型亮氨酰-tRNA 合成酶 (LeuRS) 抑制剂 (IC50=0.31 μM),从而抑制蛋白质合成。
Cas No.1234563-16-6
别名3-[[(3S)-3-(氨基甲基)-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环-7-基]氧基]-1-丙醇盐酸盐,Epetraborole,GSK2251052
化学名3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-1-propanol, monohydrochloride
Canonical SMILESOB1O[C@H](CN)C2=CC=CC(OCCCO)=C21.Cl
分子式C11H16BNO4o HCl
分子量273.5
溶解度≤10mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].

The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. The leucyl-tRNA synthetase has been involved in catalyzing the ATP-dependent ligation of L-leucine to tRNA. It has been found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain [2].

AN3365 potently and selectively inhibited bacterial leucyl-tRNA synthetase activity against Gram-negative bacteria. AN3365 was a member of a novel class of boron-containing compounds, the aminomethyl benzoxoaboroles, which showed potential to combat multidrug resistance. AN3365 was active against many microbial strains, including strains of Enterobacteriaceae with the MIC50/90 of 0.5/1 μg/ml. AN3365 showed activity against the non-fermentative Gram-negative clinical isolates P. aeruginosa, A. baumannii, S. maltophilia, and B. cepacid with the MIC50/90s of 4/8, 4/8, 2/4, and 8/32 μg/ml, respectively [1].

References:
[1] Hernandez V, Crépin T, Palencia A, et al. Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria[J]. Antimicrobial agents and chemotherapy, 2013, 57(3): 1394-1403.
[2] Rouget P, Chapeville F. Leucyl‐ RNA Synthetase[J]. European journal of biochemistry, 1971, 23(3): 443-451.