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Rimantadine Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rimantadine Hydrochloride图片
CAS NO:1501-84-4
包装与价格:
包装价格(元)
25mg电议
50mg电议

产品介绍
盐酸金刚乙胺是一种抗流感病毒药物。
Cas No.1501-84-4
别名盐酸金刚乙胺
化学名(R)-1-((1s,3R,5S,7S)-adamantan-1-yl)ethanamine hydrochloride
Canonical SMILESN[C@H](C)[C@]1(C[C@H]2C3)C[C@@H](C2)C[C@H]3C1.Cl
分子式C12H22ClN
分子量215.76
溶解度≥ 21.6mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rimantadine hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

In a variety of tissue culture systems, rimantadine (25 μg/ml) completely suppressed the growth of dengue virus type 2 in human peripheral blood leukocytes (PBL). Rimantadine significantly inhibited dengue virus replication in cultures of rhesus monkey PBL. In virus-infected LLC-MK2 cell cultures, rimantadine decreased the production of all four types of dengue virus [1]. Rimantadine interfered with the generation of cellular immune responses. Rimantadine hydrochloride inhibited the proliferative response of human peripheral blood lymphocytes to mitogenic and antigenic stimulation. Rimantadine hydrochloride (25 μg/ml) suppressed the responses to phytohemagglutinin, pokeweed mitogen, and concanavalin A by 25, 65, and 90%, respectively. rimantadine (10 μg/ml) significantly inhibited responses to streptokinase-streptodornase, tetanus toxoid, and A2/Aichi influenza vaccine [2]. In a randomized, double-blind trial involving patients with uncomplicated influenza A H3N2 subtype virus infection, rimantadine (200 mg/day for 5 days) significantly reduced nasal secretion viral titers (days 2 through 4), maximal temperature (days 2 and 3), time until defervescence (mean, 37 h shorter), and systemic symptoms [3].

References:
[1] Koff W C, Elm Jr J L, Halstead S B.  Suppression of dengue virus replication in vitro by rimantadine hydrochloride[J]. The American journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] Koff W C, Peavy D L, Knight V.  Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[J]. Infection and immunity, 1979, 23(3): 665-669.
[3] Hayden F G, Monto A S.  Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults[J]. Antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.