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Leucomycin A1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Leucomycin A1图片
CAS NO:16846-34-7
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
major metabolite of macrolide antibiotics
Cas No.16846-34-7
别名Kitasamycin A1,3-deacetyl Josamycin,Leucomycin V 4-isovalerate,9-dihydro Niddamycin,Turimycin H5
化学名4B-(3-methylbutanoate) leucomycin V
Canonical SMILESO=C1C[C@H]([C@@H]([C@H]([C@H](C[C@H]([C@H](/C=C/C=C/C[C@H](O1)C)O)C)CC=O)O[C@@]2(O[C@@H]([C@H]([C@@H]([C@H]2O)N(C)C)O[C@]3(C[C@@](O)([C@H]([C@@H](O3)C)OC(CC(C)C)=O)C)[H])C)[H])OC)O
分子式C40H67NO14
分子量786.0
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leucomycin A1, a major metabolite extracted from the leucomycin complex, is a major macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis.

Leucomycin A1 is one of the more potent members of leucomycin complex. Leucomycin complex (kitasamycin) is effective against a wide spectrum of pathogens, such as Gram-positive bacteria, Gram-negative cocci, mycoplasma, and Leptospira. Leucomycin complex has been used as an animal health product for control of Gram positive bacteria, Gram negative cocci, mycoplasma, and Leptospira. Until now, little is known about the activity of individual analogues within the complex. At a concentration of 1.56μg/ml, kitasamycin inhibited all isolates of Diplococcus pneumonia [2]. Each component of leucomycins potently inhibited the growth of Gram-positive bacteria and showed not so strong activity against the Gram-negative bacteria. Each component showed the same tendency towards the antibacterial spectrum [3].

References:
[1] Hata T, Sano Y, Ohki N, et al.  Leucomycin, a new antibiotic[J]. The Journal of antibiotics, 1953, 6(2): 87-89.
[2] Balducci Y, BODEY G P.  In vitro activity of kitasamycin against gram-positive cocci[J]. The Journal of antibiotics, 1974, 27(7): 516-519.
[3] Omura S, Katagiri M, Umezawa I, et al.  Structure-biological activities relationships among leucomycins and their derivatives[J]. The Journal of antibiotics, 1968, 21(9): 532-538.