您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > BW 723C86 hydrochloride
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
BW 723C86 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BW 723C86 hydrochloride图片
CAS NO:160521-72-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
BW 723C86 hydrochloride 是一种有效的选择性 5-HT2B 受体激动剂。
Cas No.160521-72-2
别名BW723C86盐酸盐
化学名(R)-1-(5-(thiophen-2-ylmethoxy)-1H-indol-3-yl)propan-2-amine hydrochloride
Canonical SMILESN[C@H](C)CC(C1=C2)=CNC1=CC=C2OCC3=CC=CS3.Cl
分子式C16H18N2OS.HCl
分子量322.85
溶解度DMF: >55 mg/ml,DMSO: >52 mg/ml,Ethanol: >6 mg/ml,PBS pH 7.2: >160 µ g/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BW 723C86 hydrochloride is a selective agonist of 5-HT2B receptor [1].

The 5-HT2B receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and plays an important role in shape changes in platelets, contraction of blood vessels and neuronal sensitization to tactile stimuli.

BW 723C86 hydrochloride is a selective 5-HT2B receptor agonist. BW723C86 reversibly increased both the amplitude and frequency of miniature excitatory postsynaptic currents (mEPSCs) in cardiac vagal neurons (CVNs), which were blocked by P2 receptor antagonist PPADS. And BW723C86 facilitated excitatory purinergic neurotransmission to CVNs via P2X receptor [2].

In a rat social interaction test, BW 723C86 (3 or 10 mg/kg) increased total interaction and induced an anxiolytic-like action, which was mediated by 5-HT2B receptor [1]. In a rat Vogel conflict test, BW 723C86 (10 or 30 mg/kg) increased the number of punishments, which were mediated by 5-HT2B receptor and were consistent with its anxiolytic-like properties [3]. In a neuropathic pain rat model, BW723C86 significantly inhibited mechanical allodynia and cold allodynia in a dose-dependent way [4].

References:
[1].  Kennett GA, Bright F, Trail B, et al. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. Br J Pharmacol, 1996, 117(7): 1443-1448.
[2].  Dergacheva O, Wang X, Kamendi H, et al. 5HT2 receptor activation facilitates P2X receptor mediated excitatory neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Neuropharmacology, 2008, 54(7): 1095-1102.
[3].  Kennett GA, Trail B, Bright F. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology, 1998, 37(12): 1603-1610.
[4].  Urtikova N, Berson N, Van Steenwinckel J, et al. Antinociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain. Pain, 2012, 153(6): 1320-1331.