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4-IBP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4-IBP图片
CAS NO:155798-08-6
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
4-IBP 是一种选择性 σ1 激动剂，对 σ1 受体具有高亲和力 (Ki = 1.7 nM)，对 σ2 受体具有中等亲和力 (Ki = 25.2 nM)。
Cas No.155798-08-6
化学名N-(1-benzylpiperidin-4-yl)-4-iodobenzamide
Canonical SMILESIC1=CC=C(C=C1)C(NC2CCN(CC3=CC=CC=C3)CC2)=O
分子式C19H21IN2O
分子量420.29
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 100µ g/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .IC50 value: 1.7 nM (Ki)Target: σ1in vitro: 4-IBP is a σ1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells. 4-IBP is used to investigate whether targeting theσ1 receptor could modify in vitro the migration rates of human cancer cells and increase the sensitivity of metastasizing human A549 NSCLC cells and infiltrating human glioblastoma cells to cytotoxic insults of either proapoptotic or proautophagic drugs.[1]in vivo: 4-IBP increases the antitumor effects of temozolomide and irinotecan in immunodeficient mice that were orthotopically grafted with invasive cancer cells.[1]

References:
[1]. Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2