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2-MPMDQ
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-MPMDQ图片
CAS NO:149847-77-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
α1-adrenoceptor antagonist,potent and selective
Cas No.149847-77-8
化学名(R)-2-((4-(2-methoxyphenyl)piperazin-1-yl)methyl)-6-methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
Canonical SMILESO=C1N2C[C@@H](CN3CCN(C4=CC=CC=C4OC)CC3)N=C2C5=CC=CC=C5N1C
分子式C23H27N5O2
分子量405.5
溶解度<20.27mg/ml in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-MPMDQ is a potent and selective antagonist of α1-adrenoceptor [1].

α1-adrenoceptor is a G protein-coupled receptor and mediates noradrenaline and adrenaline signal in the central and peripheral nervous systems. Also, α1-adrenoceptor mediates smooth muscle contraction.

2-MPMDQ is a potent and selective α1-adrenoceptor antagonist. In spontaneously hypertensive rats, 2-MPMDQ showed antihypertensive activity [1].

Reference:
[1].  Chern JW, Tao PL, Yen MH, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem, 1993, 36(15): 2196-2207.