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Alizarin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Alizarin图片
CAS NO:72-48-0
规格:≥98%
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议
50g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)240.21
FormulaC14H8O4
CAS No.72-48-0
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 48 mg/mL (199.8 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
SMILESO=C1C2=C(C=CC=C2)C(C3=CC=C(O)C(O)=C13)=O
SynonymsAnthraquinonic
实验参考方法
In Vitro

In vitro activity: Alizarin weakly inhibits CYP2A6 and CYP2E1. Alizarin shows competitive inhibition against CYP1B1 with Ki of 0.5 μM. Alizarin reduces the mutagenicity of MeIQx, which induced by each CYP1A2 or CYP1B1, while does not effectively reduce the mutation induced by B[a]P. Alizarin exhibits antioxidants against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes.


Cell Assay: Alizarin is proved to have anti-tumor efficacy. It suppresses the cell growth of the prostate cancer, breast cancer and osteosarcoma cell lines in vitro. Among these, the osteosarcoma cells appear to be most sensitive. The IC50 values of Alizarin against three osteosarcoma cell lines Saos-2, MG-63 and U-2 OS are 27.5, 29 and 69.9μg/ml, respectively. Alizarin inhibits the cell growth through cell proliferation blockade rather than induction of apoptosis. It inhibits the phosphorylation of ERK. In addition, Alizarin is also found to induce S-phase arrest as well as a decrease of the G0/G1 and G2/M phases.

In VivoAlizarin also reduces the hepatic content of thiobarbituric acid-reactive substances and the serum level of alanine aminotransferase in poisoned animals
Animal model
Formulation & Dosage
References

Mutat Res. 2002 Oct 31;508(1-2):147-56.