您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Sodium Danshensu
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Sodium Danshensu
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium Danshensu图片
CAS NO:67920-52-9
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)220.15
FormulaC9H9O5.Na
CAS No.67920-52-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 7 mg/mL (31.8 mM)
Water: 2 mg/mL (9.1 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)

Chemical Name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt

InChi Key: ZMMKVDBZTXUHFO-UHFFFAOYSA-M

InChi Code: InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1

SMILES Code: OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+]

Synonyms

Danshensu sodium; Sodium Danshensu; (±)-DanShenSu sodium salt

实验参考方法
In Vitro

In vitro activity: Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium.


Cell Assay: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells

In VivoThoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammatio
Animal modelRats
Formulation & Dosage
References

Food Chem Toxicol. 2008 Jan;46(1):73-81; Acta Pharmacol Sin. 2010 Apr;31(4):421-8; Toxicol Mech Methods. 2010 Oct;20(8):510-4.