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2-chloro Palmitic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-chloro Palmitic Acid图片
CAS NO:19117-92-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
2-氯棕榈酸是一种炎症脂质介质,可干扰蛋白质棕榈酰化,诱导 ER 应激标记,降低 ER ATP 含量,并激活 IL-6 的转录和分泌以及 IL-8.2-氯棕榈酸破坏线粒体膜电位并诱导 procaspase-3 和 PARP 裂解。2-氯棕榈酸可以穿过血脑屏障 (BBB) 并损害人脑内皮细胞系 hCMEC/D3 中的 ER 和线粒体功能。
Cas No.19117-92-1
别名2-氯十六烷酸
Canonical SMILESCCCCCCCCCCCCCCC(Cl)C(O)=O
分子式C16H31ClO2
分子量290.9
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.