| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
Cell lines | The human pancreatic carcinoma cell line MIA PaCa-2 |
Preparation Method | MIA PaCa-2 cellsincubated with 10 μm MG132. The cells were then incubated with Hyaluronic acid for 1 h or with 100 ng/ml PMA for 30 min at 37 ℃ in the presence of 10 μm MG132, and the culture supernatants were collected for analysis by enzyme-linked immunosorbent assay (ELISA). |
Reaction Conditions | 5-100ug/ml Hyaluronic acid for 1 h |
Applications | Hyaluronic acid oligosaccharides of a specific size range induce CD44 cleavage from tumor cells. |
Animal models | Male nude mice, 6 to 8 weeks old and weighing 22 to 28 g |
Preparation Method | The back of each mouse was divided into 4 regions that randomly received different treatments: no treatment, 0.30 mL Biohyalux ( Hyaluronic acid group), 0.30 mL fat (FAT group), and lumps formed by serial injection of 0.30 mL Biohyalux and 0.30 mL fat ( Hyaluronic acid /FAT group) |
Dosage form | 0.30 mL Hyaluronic acid |
Applications | The expression levels of CD31 and vascular endothelial growth factor (VEGF) in the Hyaluronic acid/FAT group were higher than those in the FAT group, but the difference was only significant for VEGF expression. |
| 产品描述 | Hyaluronic acid (HA) is a biopolymer composed of repeating units of disaccharides, which include molecules of D-glucuronic acid and N-acetylglucosamine molecules linked by β- (1 4) and β- (1 3)glycosides. It belongs to a group of substances called mucopolysaccharides belonging to the glycosaminoglycans (GAGs) family[1]. Hyaluronic acid also plays an important role in wound healing, ovulation, fertilization, signal transduction, and tumor physiology[2,3]. Hyaluronic acid oligosaccharides of a specific size range induce CD44 cleavage from tumor cells. It raise the possibility that small Hyaluronic acid oligosaccharides, which are known to occur in various tumor tissues, promote tumor invasion by enhancing the tumor cell motility that may be driven by CD44 cleavage[4]. Hyaluronic acid enhances tumor cell adhesion and migration and activates the Ras-mitogen-activated protein kinase pathway as well as the phosphoinositide 3-kinase pathway[5]. Purified autologous adipose-derived stem cells (ADSCs) combined with Hyaluronic acid facilitated adipose tissue regeneration in a rabbit subcutaneous model[7]. In mice, Cross-linked Hyaluronic acid had minimal effect on the early retention rate of surrounding fat grafts, but enhanced their vascularization. Fat grafts should be not injected into lumps of cross-linked HA. Therefore, agglomerated cross-linked Hyaluronic acid should be dissolved before fat transplantation[6]. Hyaluronic acid-NP treatment of diet-induced obese (DIO) mice reduced the epididymal fat mass and suppressed the induction of adipogenic and lipogenic regulators, while these effects were attenuated in the CD44-null mice[8]. In the animal study, the mice were fed a high-fat diet and treated with Clenbuterol by oral administration, or injected with Clenbuterol-modified Hyaluronic acid hydrogel (HAC) regularly. Both groups showed reduction in whole-body, visceral, and gonadal fat contents and body weight. The abdominal fat was analyzed using MRI imaging in adipose mode and water mode. The abdominal fat ratio in the mice treated with normal diet and those given intra-adipose injections with HAC had the lowest value among the test groups[9]. References: |
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