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R-IMPP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R-IMPP图片
CAS NO:2133832-83-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
R-IMPP是一种PCSK9分泌的抑制剂。
Cas No.2133832-83-2
别名PF-00932239
Canonical SMILESO=C(N(C1=NC=CC2=C1C=CC=C2)[C@H]3CNCCC3)CCC4=CC=C(OC)C=C4
分子式C24H27N3O2
分子量389.49
溶解度DMSO : ≥ 41 mg/mL (105.27 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

R-IMPP is an inhibitor of PCSK9 secretion.

R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes[1].

[1]. Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371