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NS-11394
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS-11394图片
CAS NO:951650-22-9
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 353.42
Formula C23H19N3O
CAS No. 951650-22-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 43 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES Code N#CC1=CC=CC=C1C2=CC=CC(N3C4=CC=C(C(C)(O)C)C=C4N=C3)=C2
Synonyms NS-11394; NS 11394; NS11394
实验参考方法
In Vitro

In vitro activity: NS11394 is unique in having superior efficacy at GABA(A)-alpha(3) receptors while maintaining low efficacy at GABA(A)-alpha(1) receptors. NS11394 has an excellent pharmacokinetic profile, which correlates with pharmacodynamic endpoints (CNS receptor occupancy), yielding a high level of confidence in deriving in vivo conclusions anchored to an in vitro selectivity profile and allowing for translation to higher species


Kinase Assay: NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5)> alpha(3)> alpha(2)> alpha(1) at GABA(A) alpha subunit-containing receptors.


Cell Assay:

In VivoOral administration of NS11394 (1-30 mg/kg) to rats attenuated spontaneous nociceptive behaviors in response to hindpaw injection of formalin and capsaicin, effects that were blocked by the benzodiazepine site antagonist flumazenil
Animal model Mice
Formulation & Dosage 1-30 mg/kg; i.v. and p.o.
References J Pharmacol Exp Ther. 2008 Dec;327(3):969-81.J Pharmacol Exp Ther. 2008 Dec;327(3):954-68.