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Mizoribine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mizoribine图片
CAS NO:50924-49-7
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Mizoribine (NSC 289637) 抑制?HCV?RNA 复制,具有抗 HCV 活性,IC50?约为 100 μM。Mizoribine 是一种免疫抑制剂。Mizoribine 抑制?IMPDH。Mizoribine 抑制?SARS-CoV?复制,对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50?分别为 3.5 μg/mL 和 16 μg/mL。
Cas No.50924-49-7
别名咪唑立宾; NSC 289637; HE 69
化学名1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide
Canonical SMILESC1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
分子式C9H13N3O6
分子量259.22
溶解度≥ 88.2mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mizoribine (NSC 289637; HE 69), an imidazole nucleoside, has been used as an immunosuppressive agent. Mizoribine (NSC 289637; HE 69) also is an Hsp60 inhibitor.

References:
[1]. Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575-97.
[2]. Aizawa T, et al. Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: A possible benefit of its use in the treatment of lupus nephritis. Nephrology (Carlton). 2014 Jan;19(1):47-52.
[3]. Zhang M, et al. Study of the efficacy of mizoribine in lupus nephritis in Chinese patients. Rheumatol Int. 2013 Nov;33(11):2737-42.