CAS NO: | 2126803-41-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | RIP2 Kinase Inhibitor 4 is a potent and selectiveRIPK2PROTAC. RIP2 Kinase Inhibitor 4 effectively degradesRIPK2(pIC50of 8) and inhibits the release of related TNF-α[1]. | ||
IC50& Target[1] |
| ||
体外研究 (In Vitro) | RIP2 Kinase Inhibitor 4 (Compound 20) utilizes a novel inhibitor of apoptosis (IAP) binder. RIP2 Kinase Inhibitor 4 possess comparatively reduced binding potency at both cIAP1 and XIAP BIR3 domains and increased potency at the XIAP BIR2 domain[1]. | ||
体内研究 (In Vivo) | The initial in vivo assessment of RIP2 Kinase Inhibitor 4 (Compound 20) in rats dosed at 0.5 mg/kg SC demonstrated high levels of RIPK2 degradation and inhibition of MDP-stimulated TNFα release at the final 48 h time point[1]. | ||
分子量 | 1045.21 | ||
Formula | C50H66F2N14O7S | ||
CAS 号 | 2126803-41-4 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |