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RIP2 Kinase Inhibitor 4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RIP2 Kinase Inhibitor 4图片
CAS NO:2126803-41-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
RIP2 Kinase Inhibitor 4,一种有效且选择性的RIPK2 PROTAC,可有效降解 RIPK2 (pIC50of 8) 并抑制相关 TNF-α 的释放。
生物活性

RIP2 Kinase Inhibitor 4 is a potent and selectiveRIPK2PROTAC. RIP2 Kinase Inhibitor 4 effectively degradesRIPK2(pIC50of 8) and inhibits the release of related TNF-α[1].

IC50& Target[1]

cIAP1

 

RIPK2

8 (pIC50)

体外研究
(In Vitro)

RIP2 Kinase Inhibitor 4 (Compound 20) utilizes a novel inhibitor of apoptosis (IAP) binder. RIP2 Kinase Inhibitor 4 possess comparatively reduced binding potency at both cIAP1 and XIAP BIR3 domains and increased potency at the XIAP BIR2 domain[1].
RIP2 Kinase Inhibitor 4 (Compound 20) recruits the IAP E3 ligases and shows markedly reduced inhibition of muramyl dipeptide (MDP)-stimulated TNFα production in human peripheral blood mononuclear cells (PBMCs) (pIC50of 9.3)[1].

体内研究
(In Vivo)

The initial in vivo assessment of RIP2 Kinase Inhibitor 4 (Compound 20) in rats dosed at 0.5 mg/kg SC demonstrated high levels of RIPK2 degradation and inhibition of MDP-stimulated TNFα release at the final 48 h time point[1].

分子量

1045.21

Formula

C50H66F2N14O7S

CAS 号

2126803-41-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.