| CAS NO: | 1453097-13-6 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 318.37 |
|---|---|
| Formula | C19H18N4O |
| CAS No. | 1453097-13-6 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: ≥ 34 mg/mL |
| Water: <1 mg/mL | |
| Ethanol: | |
| SMILES Code | OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3 |
| Synonyms | HUHS015; HUHS 015; HUHS-015 |
| In Vitro | In vitro activity: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. |
| Animal model | Mouse xenograft model |
| Formulation & Dosage | |
| References | Bioorg Med Chem Lett. 2014 Feb 15;24(4):1071-4. |
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