您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SCH-58261
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SCH-58261
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH-58261图片
CAS NO:160098-96-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 345.36
Formula C18H15N7O
CAS No. 160098-96-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 69 mg/mL (199.79 mM)
Water: <1 mg/mL
Ethanol: N/A
Solubility (In vivo)Chemical Name: 2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
InChi Key: UTLPKQYUXOEJIL-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)
SMILES Code: NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14
SynonymsSCH-58261; SCH 58261; SCH58261
实验参考方法
In Vitro

In vitro activity: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM).


Kinase Assay: SCH 58261 is a novel, potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively


Cell Assay: SCH 58261 decreases cell viability in a concentration-dependent in the NSCLC cell line H1975.

In VivoIt was demonstrated that the selective antagonist of the A2A receptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days.
Animal modelRat
Formulation & DosageDissolved in Tween 80 (1 %) and administered (0.01 mg/kg, i.p.) twice/day for 7 days.
References J Neuroinflammation. 2011 Apr 12;8:31.