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Lewis y tetrasaccharide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lewis y tetrasaccharide图片
CAS NO:82993-43-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Lewis y
产品介绍
Lewis Y tetrasaccharide (Lewis Y, LeY) 是 Lewis X trisaccharide (HY-N10534) 的四糖衍生物。Lewis Y tetrasaccharide 是一种与恶性卵巢癌转移和预后不良相关的抗原。
生物活性

Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form ofLewis X trisaccharide(HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

体外研究
(In Vitro)

Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells[1].
Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of LeY(RMG-1-hFUT)[2].
Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells[2].
Anti-LeYantibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo[2].

分子量

675.63

Formula

C26H45NO19

CAS 号

82993-43-9

结构分类
  • Saccharides
  • Polysaccharides
来源

human

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.