包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | CP-547632 TFA is an orally active, ATP-competitive and potentVEGFR-2andFGFkinases inhibitor withIC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF overEGFR,PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC50value of 6 nM[1]. Western Blot Analysis[1]
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体内研究 (In Vivo) | CP-547632 TFA (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts[1].
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Clinical Trial | |||||||||||||||||
分子量 | 646.43 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H25BrF5N5O5S | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 150 mg/mL(232.04 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |