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Nintedanib-13C,d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nintedanib-13C,d3图片
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
BIBF 1120-13C,d3
产品介绍
Nintedanib-13C,d3 是一种 13C- 和氘代标记的 Nintedanib。Nintedanib (BIBF 1120) 是一种有效的三重血管激酶抑制剂,抑制VEGFR1/2/3FGFR1/2/3PDGFRα/βIC50值分别为 34 nM/13 nM/13 nM,69 nM/37 nM/108 nM 和 59 nM/65 nM。
生物活性

Nintedanib-13C,d3 is the 13C- and deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[77].

分子量

543.64

性状

Solid

Formula

C3013CH30D3N5O4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month