CAS NO: | 882531-87-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | R1530 is a highly potent, orally active, dual-actingmitosis/angiogenesisinhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases withKdvalues of<500 nm. r1530 inhibits vgfr2 andFGFR1withIC50of 10 nM and 28 nM, respectively. R1530 triggersapoptosis(mitotic catastrophe) or senescence[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | R1530 exhibits potent in vitro antiproliferative activity in all of the tumor cell lines (IC50= 0.2–3.4 μM)[1]. | ||||||||||||||||
体内研究 (In Vivo) | R1530 (1.56, 25, and 50 mg/kg; p.o.; daily, for 28 days.) has notable antitumor activity across a broad range of human xenograft models, with minimal toxicity[1].
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分子量 | 356.78 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H14ClFN4O | ||||||||||||||||
CAS 号 | 882531-87-5 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 50 mg/mL(140.14 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |