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Picrasidine Q
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Picrasidine Q图片
CAS NO:101219-61-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Picrasidine Q 是从当归植物中提取的生物碱成分,具有抗细胞转化和抗癌作用。Picrasidine Q 诱导人食管癌细胞凋亡和G1 期阻滞,并直接抑制FGFR2激酶活性。
生物活性

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cellapoptosisand G1 phase arrest in human esophagealcancercell lines, and directly inhibitsFGFR2kinase activity[1].

IC50& Target[1]

FGFR2

 

体外研究
(In Vitro)

Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].

Western Blot Analysis[1]

Cell Line:ESCC cells
Concentration:0~60 μM
Incubation Time:3 hours
Result:Suppressed downstream signaling of FGFR2 in ESCC cells.

Apoptosis Analysis[1]

Cell Line:ESCC cells
Concentration:0~60 μM
Incubation Time:48 and 72 hours
Result:Induced cell cycle arrest and apoptosis.

Cell Cytotoxicity Assay[1]

Cell Line:ESCC cells
Concentration:0~60 μM
Incubation Time:24~72 hours
Result:Suppressed the growth of ESCC cells.

Cell Cycle Analysis[1]

Cell Line:JB6Cl41 cells
Concentration:0~60 μM
Incubation Time:30 minutes
Result:Inhibited proliferation by inhibition of G1/S cell cycle transition.
分子量

266.25

Formula

C15H10N2O3

CAS 号

101219-61-8

结构分类
  • Alkaloids
  • Quinoline Alkaloids
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.