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AZ7550
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ7550图片
CAS NO:1421373-99-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AZ7550 是 AZD9291 的一种活性代谢物,AZ7550 抑制IGF1R活性,IC50为 1.6 μM。
生物活性

AZ7550 is an active metabolite of AZD9291 and inhibits the activity ofIGF1Rwith anIC50of 1.6 μM.

IC50& Target

IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2), 302 nM (FLT3), 420 nM (ALK ), 449 nM (FES), 840 nM (IRR), 843 nM (BRK), 977 nM (BLK), 995 nM (FAK), 1256 nM (Ins R), 1317 nM (TEC), 1784 nM (FLT4), 2288 nM (PYK2), 2443 nM (Txk), 5104 nM (BTK)[1]

体外研究
(In Vitro)

AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively[1].

Clinical Trial
分子量

485.58

Formula

C27H31N7O2

CAS 号

1421373-99-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.