您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Tetromycin A
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tetromycin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetromycin A图片
CAS NO:180027-83-2
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.180027-83-2
化学名(9CI)-(1S,4S,4aS,6aR,7E,11E,12aR,15R,16aS,20aS,20bR)-4-(acetyloxy)-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,6,7,11,12a,14,15,20a-octamethyl-18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione
Canonical SMILESCC1=C[C@@]2([H])[C@@]([C@@](C(C3=C4O)=O)(C)[C@]1([H])/C(C)=C/CC/C(C)=C/[C@@]5(C)[C@@]4(OC3=O)C[C@@H](C)C(C)=C5)([H])[C@@H](C)CC[C@@H]2OC(C)=O
分子式C36H48O6
分子量576.8
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetromycin A, as an unusual tetronic acid, is a tetronic acid-based antibiotic. It is structurally related to saccharocarcin, chlorothricin, tetrocarcin, kijanimicin and versipelostatin and has been shown to be active against antibiotic resistant and susceptible Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). MRSA is a strain of bacteria which cannot be killed by a wide range of antibiotics, including methicillin, penicillin, and oxacillin, and causes infections in different parts of the body. The derivatives of tetromycin have been found to inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range and have anti-trypanosomal activity. Tetromycin A probably targets the phosphatidylinositide-3'-kinase/Akt signaling pathway.

Akt, a downstream factor in the phosphatidylinositide-3'-kinase-dependent pathway, mediates a variety of biological responses, including protein synthesis, glucose uptake and the regulation of proliferation and apoptosis, which presumably contributes to acquisition of malignant properties of human cancers [1].

In vitro: Up to now, in vitro study of Tetromycin A is still in the development stage.

In vivo: Up to now, in vivo study of Tetromycin A is still in the development stage.

Reference:
[1].  Nakajima, H., Sakaguchi, K., Fujiwara, I., Mizuta, M., Tsuruga, M., Magae, J., & Mizuta, N. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Biochemical and Biophysical Research Communications. 2007; 356(1): 260-265.