| CAS NO: | 61270-78-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Cas No. | 61270-78-8 |
| 别名 | 头孢尼西钠 |
| 化学名 | (6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt |
| Canonical SMILES | O=C(N[C@H]1[C@](SCC(CSC2=NN=NN2CS([O-])(=O)=O)=C3C([O-])=O)([H])N3C1=O)[C@H](O)C4=CC=CC=C4.[Na+].[Na+] |
| 分子式 | C18H16N6O8S3o 2Na |
| 分子量 | 586.5 |
| 溶解度 | ≥ 22.95mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cefonicid is a second-generation cephalosporin antibiotic. Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. In vitro: Cefonicid was found to be similar to cefamandole in its superiority to first generation cephalosporins against several enterobacteriaceae and Haemophilus influenzae, such as beta-lactamase-producing strains. Its activity against Staphylococcus aureus was similar to that of cefoxitin and inferior to cefamandole and first generation cephalosporins. Cefonicid has excellent in-vitro activity against Neisseria gonorrhoeae, but is inactive against Pseudomonas, Serratia, Acinetobacter, and Bacteroides fragilis [1]. In vivo: The purpose of a previous study was to determine whether cefonicid caused testicular toxicity when subcutaneously administered to Sprague-Dawley male rats at doses of 50 to 1,000 mg/kg per day. The histological findings were confirmed by marked reductions in testicular sperm production rates and cauda epididymal sperm numbers. In addition, cefonicid had no treatment-related adverse effects on the sexual maturation males [2]. Clinical trial: Cefonicid was found to be comparable in efficacy with cefamandole or cefazolin in the treatment of patients with urinary tract, lower respiratory tract, and soft tissue and bone infections. It was also compared with penicillin in the treatment of uncomplicated gonorrhoea. Single doses of cefonicid appear to offer a similar degree of protection against post-surgical infection as multiple doses of other antibiotics [1]. References: |
m.cnreagent.com