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Cefoperazone(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefoperazone(sodium salt)图片
CAS NO:62893-20-3
包装与价格:
包装价格(元)
1g电议
5g电议
10g电议

产品介绍
Cefoperazone (sodium salt) (CP 52640-2) 是一种半合成头孢菌素,具有广谱抗菌活性。
Cas No.62893-20-3
别名头孢哌酮钠; CP 52640-2
化学名(6R,7R)-7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
Canonical SMILESCCN(CCN(C(N[C@H](C1=CC=C(O)C=C1)C(N[C@@H]2C(N3[C@]2([H])SCC(CSC4=NN=NN4C)=C3C([O-])=O)=O)=O)=O)C5=O)C5=O.[Na+]
分子式C25H26N9O8S2o Na
分子量667.7
溶解度≤20mg/ml in DMSO;15mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

In vitro: There was only a small spread between the minimum inhibitory concentrations and the minimum bactericidal concentrations of cefoperazone and a significant decrease in activity with an increase in inoculum size. Cefoperazone is relatively stable to hydrolysis to β-lactamases produced by gram-negative bacteria. Relative rates of hydrolysis of cefoperazone by cephalosporinases were 7.0 to 0.01[1]. In 50 strains of N. gonorrhoeae, the MIC50 of cefoperazone was ≤ 0.004-0.06 μg/ml [2].

In vivo: In four patients with cholelithiasis and one patient with carcinoma of the head of the pancreas, all of whom had normal renal functions, cefoperazone was intravenously administrated. In common duct bile, the maximum concentrations of cefoperazone ranged from 373.4 to 3,100 μg/ml while the concentrations ranged from 6.8 to 680 μg/ml in gall bladder bile. Cefoperazone concentrations of the gall bladder wall ranged from 16.8 to 48.0 μg/g [3].

References:
[1] Matsubara N, Minami S, Muraoka T, et al.  In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin[J]. Antimicrobial agents and chemotherapy, 1979, 16(6): 731-735.
[2] Baker C N, Thornsberry C, Jones R N.  In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains[J]. Antimicrobial agents and chemotherapy, 1980, 17(4): 757-761.
[3] Nakamura T, Hashimoto I, Sawada Y, et al.  Cefoperazone concentrations in bile and gall bladder wall after intravenous administration[J]. Antimicrobial agents and chemotherapy, 1980, 18(6): 980-982.