| CAS NO: | 1613465-33-0 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1613465-33-0 |
| 别名 | (E)-2-((1,4-二甲基哌嗪-2-亚基)氨基)-5-硝基-N-苯基苯甲酰胺 |
| 化学名 | 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-benzamide |
| Canonical SMILES | CN1CCN(C)C/C1=N\C2=C(C(NC3=CC=CC=C3)=O)C=C([N+]([O-])=O)C=C2 |
| 分子式 | C19H21N5O3 |
| 分子量 | 367.4 |
| 溶解度 | ≤0.2mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 32, 20, and 41 nM for TC-83, V3526, and Trinidad donkey strains, respectively. ML-336 is an inhibitor for VEEV-induced cytopathic effect. Alphaviruses like Venezuelan Equine Encephalitis Virus (VEEV) are positive-sense, enveloped, single stranded RNA viruses that are widely geographically distributed. VEEVs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans. In vitro: ML336 was identified as a first-in-class probe that inhibited a VEEV-induced cytopathic effect in three strains of the virus, which were V3526, TC-83, and Trinidad donkey, in the low nanomolar range without having cytotoxicity (>50 μM, selectivity index >1500). In addition, ML336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μM drug concentration. Furthermore, ML336 showed a favorable in vitro PK profile that included moderate blood-brain barrier permeability. More importantly, ML336 seemed to be able to target the VEEV [1]. In vivo: Currently, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted. Reference: |
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