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Cefamandole(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefamandole(sodium salt)图片
CAS NO:30034-03-8
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议

产品介绍
头孢孟多钠盐是第二代广谱头孢菌素抗生素。
Cas No.30034-03-8
别名头孢孟多酯钠; Cephamandole sodium
化学名(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
Canonical SMILESO=C(N[C@@H]1C(N2[C@]1([H])SCC(CSC3=NN=NN3C)=C2C([O-])=O)=O)[C@H](O)C4=CC=CC=C4.[Na+]
分子式C18H17N6O5S2o Na
分子量484.5
溶解度≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MIC: 0.25-2 mg/L for different E. coli strains

Cefamandole is a cephalosporin antibiotic.

The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

In vitro: The in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. Against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. None of the Pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].

In vivo: The testicular toxicity of cefamandole was evaluated in neonatal rats. Results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. In rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].

Clinical trial: A randomized, single-blind comparison of parenteral cefamandole and ampicillin was conducted in adult patients with pneumonia or purulent tracheobronchitis. Results showed that cefamandole was as effective and safe as ampicillin. Of the 14 patients treated with cefamandole, 13 were considered cured, as were 12 of the 13 treated with ampicillin [3].

References:
[1] Eickhoff TC, Ehret JM.  In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin. Antimicrob Agents Chemother. 1976 Jun;9(6):994-9.
[2] Hoover DM, Buening MK, Tamura RN, Steinberger E.  Effects of cefamandole on spermatogenic development of young CD rats. Fundam Appl Toxicol. 1989 Nov;13(4):737-46.
[3] Delgado DG, Brau CJ, Cobbs CG, Dismukes WE. Clinical and laboratory evaluation of cefamandole in the therapy of Haemophilus spp. Bronchopulmonary infections. Antimicrob Agents Chemother. 1979 Jun;15(6):807-12.