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Niranthin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Niranthin图片
CAS NO:50656-77-4
包装:5mg
市场价:6750元

产品介绍
Niranthin,一种具有广泛药理活性的木脂素。
Cas No.50656-77-4
别名珠子草素
化学名rel-6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole
Canonical SMILESCOC1=CC(C[C@@H](COC)[C@H](COC)CC2=CC(OC)=C(OC)C=C2)=CC3=C1OCO3
分子式C24H32O7
分子量432.5
溶解度DMF: 15 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 15.6 μM and 25.1 μM for inhibiting the secretion of HBsAg and HBeAg, respectively.

Niranthin is a natural lignin isolated from the genus Phyllanthus, with antiviral activities both in vitro and in vivo. Niranthin also exerts anti-inflammatory and anti-allodynic activities.

In Vitro: In human hepatoma cell line MS-G2 which synthesizes hepatitis B viral particles, Niranthin was screened among 25 pure compounds which were isolated from several phyllanthus species with the most potent anti-HBV activity (EC50= 33.6 μM) by effectively suppressing the expression of HBsAg and HBeAg, with the highest inhibition of 74.3% [1]. Besides, in human HBV-transfected liver cell line HepG2.2.15, Niranthin could significantly inhibit the secretion of HBsAg and HBeAg after treatment for 144 h, with the IC50 values of 15.6 μM and 25.1 μM, respectively [2].

In Vivo: In duck hepatitis B virus (DHBV) infected ducks, intragastric administration of Niranthin could significantly decrease the plasma DHBV DNA levels, with the mean inhibition percentage of 70.72%, 75.23%, and 90.87% at the dose of 25, 50, and 100 mg/kg/day, respectively. Niranthin could also significantly inhibit the serum HBsAg, HBeAg, ALT, and AST levels [2].

Clinical trial: no data available.

References:
[1] Huang R, Huang Y, Ou J, et al.  Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro[J]. Phytotherapy Research, 2003, 17(5): 449-453.
[2] Liu S, Wei W, Li Y, et al.  In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L.[J]. Journal of Ethnopharmacology, 2014, 157(2): 1061-1067.