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Lagosin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lagosin图片
CAS NO:6834-98-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Lagosin (Fungichromin) 是一种多烯大环内酯类抗生素。 Lagosin 具有广谱抗真菌活性,并且不受耐药性影响。
Cas No.6834-98-6
别名喷他霉素,Antibiotic A 246,14-hydroxy Filipin,NSC 105388,NSC 276732
化学名(3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Canonical SMILESC/C1=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@@H]1O)=O
分子式C35H58O12
分子量670.8
溶解度DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lagosin, a polyene macrolide antibiotic, has first been extracted from an isolate of a Streptomyces species present in a sample of soil collected in Lagos, Nigeria [1]. It has been reported that the three polyene macrolide antibiotics, fungichromin, lagosin, and cogomycin, showed some stereochemical differences at one or more centers [1].

Lagosin was the most polar member of the filipin family of fungicides with broad spectrum antifungal and antitumor activity, acting via interaction with cell membrane sterols. The antibiotic lagosin, which appeared to be identical to, or a stereoisomer of, fungichromin, and was very similar in structure to the filipins [2]. The equilibrium constants for association of the polyene antibiotics with aqueous suspensions of cholesterol follow the order filipin IIl >amphotericin B >nystatin >lagosin, in agreement with the order reported for the extent of damage these antibiotics cause in natural and model membranes [2].

Reference:
[1] Pandey R C, Guenther E C, AszALos A A, et al.  Physicochemical and biological comparison of polyene macrolide antibiotics fungichromin, lagosin and cogomycin[J]. The Journal of antibiotics, 1982, 35(8): 988-996.
[2] Bittman R, Fischkoff S A.  Fluorescence studies of the binding of the polyene antibiotics filipin III, amphotericin B, nystatin, and lagosin to cholesterol[J]. Proceedings of the National Academy of Sciences, 1972, 69(12): 3795-3799.