| CAS NO: | 6152-57-4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 6152-57-4 |
| 别名 | O-甲基纯绿青霉素,AIDS-089094,3-methoxy-4-phenyl-Carbostyril,Viridicatin methyl ester |
| 化学名 | 3-methoxy-4-phenyl-2(1H)-quinolinone |
| Canonical SMILES | O=C1NC2=C(C=CC=C2)C(C3=CC=CC=C3)=C1OC |
| 分子式 | C16H13NO2 |
| 分子量 | 251.3 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 2.5 μM: inhibits virus production in OM-10.1 cells (HL-60 promyelocytes infected with HIV-1) treated with TNF-α. 5 μM: blocks activation of the HIV long terminal repeat by TNF-α in HeLa cells O-Methylviridicatin, a natural derivative of the alkaloid mycotoxin viridicatin, is produced by several species in the genus, Penicillium. It is demonstrated that O-Methylviridicatin, as an inhibitor, blocks the tumor necrosis factor alpha (TNFα)-induced replication of human immunodeficiency virus (HIV). TNFα increases the binding of the cellular transcription factor NF-κB to the HIV long terminal repeat (LTR), which directly triggers transcription of the latent provirus. In vitro: O-Methylviridicatin had an inhibitory effect on the TNFα-triggered replication of HIV LTR in HeLa cells. In addition, O-Methylviridicatin dose-dependently dampened virus production in the OM-10.1 cell line, which was measured by the output of p24 core antigen into the culture medium. It was demonstrated that the suppressive effect of O-Methylviridicatin was not reversed even if the concentration of TNFα was increased 10-fold [1]. In vivo: Up to now, in vitro study of O-Methylviridicatin is still in the development stage. Reference: |
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