CAS NO: | 702662-50-8 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 702662-50-8 |
别名 | G10 |
化学名 | (Z)-4-(2-chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carbimidic acid |
Canonical SMILES | ClC(C=CC=C1F)=C1CN(C(CS2)=O)C3=C2C=CC(/C(O)=N/CC4=CC=CO4)=C3 |
分子式 | C21H16ClFN2O3S |
分子量 | 430.88 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 0.5 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1]. G10 induces IFN/IRF3- but not NF-κB-dependent transcription in human fibroblasts[1].G10 is an indirect activator of human STING-dependent phenotypes[1].G10-mediated IRF3 activation and anti-Alphaviral activity occur independently of IPS-1/MAVS-dependent signaling[1].STING is required for G10-mediated IRF3 activation, gene expression, and anti-Alphaviral activity[1].G10 induces STING-dependent synthesis and secretion of bioactive interferon[1].G10 induces innate antiviral mRNA expression in primary human cells[1]. References: |