S961

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S961

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1083433-49-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

S961 是一种高亲和力的胰岛素受体 (insulin receptor, IR) 拮抗剂，对 HIR-A，HIR-B 和人胰岛素样生长因子 I 受体 (HIGF-IR) 的IC₅₀分别为 0.048，0.027 和 630 nM。

生物活性

S961 is an high-affinity and selectiveinsulin receptor(IR) antagonist withIC₅₀s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and humaninsulin-like growth factor Ireceptor (HIGF-IR) in SPA-assay, respectively^[1].

体外研究
(In Vitro)

S961 also shows high-affinity to Rat IR and Pig IR with IC₅₀s of 0.056 nM and 0.084 nM in PEG-assay, respectively^[1].

分子量

4804.13

Formula

C₂₁₁H₂₉₇N₅₅O₇₁S₂

CAS 号

1083433-49-1

Sequence Shortening

GSLDESFYDWFERQLGGGSGGSSLEEEWAQIQCEVWGRGCPSY (Disulfide bridge: Cys33-Cys40)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.