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Multi-kinase-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Multi-kinase-IN-1图片
CAS NO:2470807-67-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Multi-kinase-IN-1 (Compound 11k) 是一种具有抗肿瘤活性的激酶 (kinase) 抑制剂。Multi-kinase-IN-1 诱导细胞凋亡 (apoptosis),可用于结直肠癌的研究。
生物活性

Multi-kinase-IN-1 (Compound 11k) is a potentkinaseinhibitor with antitumor activity. Multi-kinase-IN-1 induces cellapoptosis, and can be studied for colorectalcancer[1].

IC50& Target

Ron

0.122 μM (IC50)

PDGFRα

0.384 μM (IC50)

c-Src

0.421 μM (IC50)

AXL

0.632 μM (IC50)

体外研究
(In Vitro)

Multi-kinase-IN-1 (Compound 11k) (0-5 μg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1].
Multi-kinase-IN-1 (0-3 μg/mL, 0-72 h) induces cell apoptosis in a time- and dose-dependent manner[1].
Multi-kinase-IN-1 (0-3 μg/mL, 48 h) slightly induces cell cycle arrest in G2/M phase[1].

Cell Proliferation Assay[1]

Cell Line:HT-29 (human colon cancer cell) and FHC (normal colorectal mucosa epithelial cells)
Concentration:0.56, 1.67, and 5 μg/mL for HT-29, 10 μg/mL for FHC
Incubation Time:0-72 h
Result:Led to significant cytotoxicity in a dose- and time-dependent manner in HT-29 cells. Showed low toxicity in FHC cells.

Apoptosis Analysis[1]

Cell Line:HT-29
Concentration:0.3, 1, and 3 μg/mL
Incubation Time:0-72 h
Result:Induced cell apoptosis in a time- and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line:HT-29
Concentration:0.3, 1, and 3 μg/mL
Incubation Time:48 h
Result:Slightly induced cell cycle arrest with a G2/M percentage of 4.4% at 3.0 mg/mL compared to 0.1% DMSO (2.4%).
分子量

706.76

Formula

C35H36F2N6O6S

CAS 号

2470807-67-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.