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Henatinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Henatinib图片
CAS NO:1239269-51-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Henatinib 是一种口服有效的小分子多激酶抑制剂,具有广泛的抗肿瘤活性。Henatinib 抑制VEGFR-2c-kitPDGFR的活性,IC50值分别为 0.6 nM、3.3 nM 和 41.5 nM。Henatinib 显著抑制人脐静脉内皮细胞 (HUVECs) 中的 VEGFR-2 磷酸化及其下游信号通路。
生物活性

Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity ofVEGFR-2,c-kit,PDGFRwithIC50values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs)[1].

IC50& Target

VEGFR-2

0.6 nM (IC50)

PDGFRα

 

PDGFRβ

 

体外研究
(In Vitro)

Henatinib shows high binding affinities for VEGFRs, PDGFR and stem cell factor receptor[1].
Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs), and consistently inhibited VEGF-stimulated HUVEC proliferation, migration and tubule formation[2].

Clinical Trial
分子量

468.52

Formula

C25H29FN4O4

CAS 号

1239269-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.