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AC710 Mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AC710 Mesylate图片
CAS NO:1351522-05-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
AC710 Mesylate 是有效的PDGFR抑制剂,对FLT3,CSF1R,KIT,PDGFRα 和 PDGFRβ的Kd值分别为0.6,1.57,1,1.3,1.0。
生物活性

AC710 Mesylate is a potentPDGFRinhibitor withKds of 0.6, 1.57, 1, 1.3, 1.0 nM forFLT3, CSF1R, KIT,PDGFRαandPDGFRβ, respectively.

IC50& Target[1]

PDGFRα

1.3 nM (Kd)

PDGFRβ

1 nM (Kd)

c-Kit

1 nM (Kd)

FLT3

0.6 nM (Kd)

CSF1R

1.57 nM (Kd)

体内研究
(In Vivo)

At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stay suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses[1].

分子量

658.81

Formula

C32H46N6O7S

CAS 号

1351522-05-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.