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Valproic acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Valproic acid-d4图片
CAS NO:87745-17-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
VPA-d4
2-Propylpentanoic Acid-d4
产品介绍
Valproic acid-d4 (VPA-d4) 是 Valproic acid 的氘代物。Valproic acid (VPA; 2-Propylpentanoic Acid) 是一种HDAC抑制剂,IC50值为 0.5-2 mM,抑制HDAC1的活性,(IC50,400 μM),同时可诱导HDAC2的降解。Valproic acid 激活Notch1信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid 可用于癫痫、双相情感障碍和偏头痛等的研究。
生物活性

Valproic acid-d4 (VPA-d4) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is anHDACinhibitor, withIC50in the range of 0.5 and 2 mM, also inhibitsHDAC1(IC50, 400 μM), and induces proteasomal degradation ofHDAC2. Valproic acid activatesNotch1signaling and inhibits proliferation in small cell lungcancer(SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

148.24

Formula

C8H12D4O2

CAS 号

87745-17-3

中文名称

丙戊酸 d4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.