Valproic acid-d4 (VPA-d4) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is anHDACinhibitor, withIC₅₀in the range of 0.5 and 2 mM, also inhibitsHDAC1(IC₅₀, 400 μM), and induces proteasomal degradation ofHDAC2. Valproic acid activatesNotch1signaling and inhibits proliferation in small cell lungcancer(SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

148.24

C₈H₁₂D₄O₂

87745-17-3

丙戊酸 d4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.