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Rp-8-CPT-cAMPS sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rp-8-CPT-cAMPS sodium图片
CAS NO:221905-35-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Rp-8-CPT-cAMPS sodium,一种 cAMP 类似物,是 cAMP 诱导的依赖 cAMP 的PKA IPKA II活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS sodium 优先选择 RI 的位点 A 与 RII 的位点 B。
生物活性

Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependentPKAIandII. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2].

IC50& Target

PKA[1]

体外研究
(In Vitro)

Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2].
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2].
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3].

分子量

509.86

Formula

C16H14ClN5NaO5PS2

CAS 号

221905-35-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.