AZD7254 是一种具有口服活性的Smoothened (SMO)抑制剂,对 sonic Hh protein (shh) 的EC50值为 1.0 nM。
生物活性 | AZD7254 is an orally activeSmoothened (SMO)inhibitor with anEC50of 1.0 nM against sonic Hh protein (shh)[1]. |
体内研究 (In Vivo) | AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |