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ALK5-IN-33
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ALK5-IN-33图片
CAS NO:2785430-89-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ALK5-IN-33 (Compound EX-10) 是一种选择性的、具有口服活性的ALK-5抑制剂,IC50不高于 10 nM。
生物活性

ALK5-IN-33 (Compound EX-10) is a selective, orally activeALK-5inhibitor with anIC50≤10 nM[1].

IC50& Target

ALK5

≤10 nM (IC50)

ALK2

 

体外研究
(In Vitro)

ALK-IN-33 (Compound EX-10) shows a high efficiency by inducing a full inhibition (max PIN greater than 75) of TGF-β1 mediated alpha-SMA expression, in at least two donors[1].

体内研究
(In Vivo)

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].

Animal Model:Female athymic nude mice, A549 xenograft model[1]
Dosage:10, 50, 75 and 100 mg/kg
Administration:Oral gavage, once
Result:Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
分子量

413.48

Formula

C23H23N7O

CAS 号

2785430-89-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.