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TGFBR1-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TGFBR1-IN-1图片
CAS NO:2170830-26-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
TGFBR1-IN-1 是一种有效的选择性ALK5抑制剂,IC50为 10-100 nM。详细信息请参考专利文献 WO2018004290A1 中的化合物 33。
生物活性

TGFBR1-IN-1 is anALK5inhibitor extracted from patent WO2018004290A1, Compound 33, has anIC50of 10-100 nM[1].

IC50& Target[1]

ALK5

10-100 nM (IC50)

体外研究
(In Vitro)

Transforming Growth Factor-β (TGF-β) signaling regulates various cellular responses such as cell proliferation, differentiation, cell migration and cell death. TGF-β has at least three isoforms TGF-β1, TGF-β2 and TGF-β3. TGF-β1 is two well-conserved single membrane serine/threonine kinase type I (ALK5). ALK5 inhibitos can be used for treating fibrotic disease, tumor, inflammatory disease, and autoimmune disease[1].

分子量

427.48

Formula

C23H17N5O2S

CAS 号

2170830-26-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.