您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > TEI-9648
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TEI-9648
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TEI-9648图片
CAS NO:173388-21-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
TEI-9648 是一种 Vitamin D3Lactone 类似物,是有效的,特异性的维生素 D 受体 (VDR) 拮抗剂。TEI-9648 抑制 VDR/VDRE 介导的 1α,25(OH)2D3的基因组作用。TEI-9648 也可以抑制 1α,25(OH)2D3诱导的 HL-60 细胞分化。TEI-9648 有潜力用于骨代谢的研究。
生物活性

TEI-9648, a Vitamin D3Lactone analogue, is a potent and specificvitamin D receptor (VDR)antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2].

体外研究
(In Vitro)

TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1].
TEI-9648 has consistently weaker suppressive effect than TEI-9647[1].
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1].
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3(0.1 nM) in HL-60 cells[1].

分子量

426.59

性状

Solid

Formula

C27H38O4

CAS 号

173388-21-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)