Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally activevitamin D receptor (VDR)agonist with aK_dof 0.53 nM. Inecalcitol can induce cellapoptosisand has potent anticancer activities^[1][2][3][4].

Kd: 0.53 nM (vitamin D receptor (VDR))^[2]

Inecalcitol (0.1-10 nM; 48 hours) treatment of LNCaP cells results in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner. Inecalcitol (0.1-10 nM; 48 hours) also decreases ETV1 expression levels in a dose-dependent manner^[1].
Inecalcitol (10-14 days) inhibits the growth of LNCaP and HL-60 cells with ED₅₀values of 4.0 nM and 0.28 nM, respectively^[1].

Inecalcitol (1.3 mg/kg; i.p.; 3 times per week; for 42 days) inhibits androgen-responsive prostate cancer growth in vivo^[1].
Pharmacokinetic studies show that plasma half-life of Inecalcitol (C57Bl/6J mice; 1.3 mg/kg; i.p.) is 18.3 minutes in mice^[1].

400.59

Solid

C₂₆H₄₀O₃

163217-09-2

伊奈骨化醇；依奈骨化醇

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

DMSO : 100 mg/mL(249.63 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light, stored under nitrogen)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。