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11-Ketodihydrotestosterone-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
11-Ketodihydrotestosterone-d3图片
CAS NO:2479914-02-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
11-KDHT-d3
5α-dihydro-11-keto Testosterone-d3
产品介绍
11-Ketodihydrotestosterone-d3 (11-KDHT-d3) 是 11-Ketodihydrotestosterone 的氘代物。11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) 是一种内源性类固醇,是 11β-羟基雄烯二酮的代谢产物。11-Ketodihydrotestosterone 是一种活性雄激素,也是一种有效的雄激素受体 (AR) 激动剂,对人ARKi为 20.4 nM,EC50为 1.35 nM。11-Ketodihydrotestosterone 在雄激素依赖性前列腺癌细胞中诱导基因调节,蛋白质表达和细胞生长。
生物活性

11-Ketodihydrotestosterone-d3 (11-KDHT-d3) is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potentandrogen receptor(AR)agonist with aKiof 20.4 nM and anEC50of 1.35 nM forhuman AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostatecancercells[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

307.44

Formula

C19H25D3O3

CAS 号

2479914-02-6

中文名称

11-酮二氢睾酮 d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.